In the wake of Hurricane Katrina, a group of New York Broadway artists come down to New Orleans to make a change. Reopening the doors of the storm-damaged St. Mark's Community Center, they hold auditions for the musical Once On This Island and stage the show with thirteen kids from the community . Captures the lives of kids and crew as they turn a gym into a theater, come together as a company, and create hope and purpose.

In New Orleans after 'Katrina', the partner of Detective Andy Devereaux is found dead, and he is teamed up with Stan Green. During the investigations, an undercover DEA agent is murdered by two dirty police officers. A psychologist, Nina Ferraro, has successive interviews with Andy, Stan and the two detectives. Meanwhile, the FBI also investigate the corruption in the police force leaded by Agent Brown.

Nolan Hayes arrives at a New Orleans hospital with his pregnant wife, Abigail, who has gone into early labor. Things quickly spiral out of control when the birth goes tragically wrong and Hurricane Katrina hits, ravaging the hospital and forcing an evacuation. With his baby dependent on a ventilator and no one around to help, Nolan faces one life-and-death decision after another and must fight to keep his daughter alive.