The world's most wanted criminal, Raymond Reddington, mysteriously turns himself in and offers to give up everyone he has ever worked with. His only condition is that he will only work with a newly minted FBI agent with whom he seemingly has no connection.

Season Three takes a heart-racing turn when Red and Agent Keen, become fugitives on the run. With Assistant FBI Director Harold Cooper under investigation, Agent Donald Ressler leads the FBI Task Force on the manhunt. As Keen delves deeper into Red's underworld of covert operations, she continues to struggle with self-discovery and her indefinable relationship with Tom. Both Red and Keen are radically challenged personally and professionally.

Bob Lee Swagger, a highly-decorated veteran coaxed back into action after learning of a plot to kill the president. When Swagger's former commanding officer, Isaac Johnson, solicits Swagger's expertise for the clandestine operation, Swagger discovers that he has been framed and must do everything in his power to protect his family and clear his name.

FBI agent Clarice Starling's involvement in a dramatic drug bust brings her once again to the attention of killer cannibal Dr. Hannibal Lecter who escaped from custody seven years earlier after helping Clarice nab a serial murderer.

Brought together to form one extraordinary team of "Alphas" - people whose unique brain anomalies imbue them with superhuman mental and physical abilities - five seemingly ordinary citizens must take the law into their own hands while working within the government to investigate a new brand of baffling crime.