When Myra agrees to date the charming but vulnerable Reggie, her eccentric brother Ludlow sets out to destroy the budding relationship, forcing Myra to finally take charge of her own life.

Jon and Wendy Savage are two siblings who have spent their adult years trying to recover from their abusive father, Lenny. Suddenly, a call comes in that Lenny's girlfriend has died and he cannot care for himself. Lenny suffers from dementia and her family dumps Lenny on his children. Despite the fact Jon and Wendy have not spoken to Lenny for twenty years and he is even more loathsome than ever, the Savage siblings feel obliged to take care of him....

Olive is a little girl who dreams of winning the Little Miss Sunshine contest. Her family wants her dream to come true, but they are so dysfunctional that they can barely make it through a day without some disaster befalling them. Olive's father, Richard, is unsuccessful as a motivational speaker. He is barely on speaking terms with Olive's mother. Her uncle Frank has attempted suicide following an unsuccessful romance with a male graduate student....

Skeeter, the handyman of a hotel once belonging to his father, agrees to watch his sister's two children and finds his life changed when the stories he tells the kids at bedtime begin to come true.